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[DOI] [PMC free article] [PubMed] [Google Scholar] 42.Spasov A.A., Wikman G.K., Mandrikov V.B., Mironova I.A., Neumoin V.V

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Aging reduces NAD+ synthesis pathways while increasing consumption by enzymes like CD38 and PARPs, activated by inflammation and damage.[13][15] CD38, an immune-related enzyme, ramps up with age, breaking down NAD+ precursors

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